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DR. J. JAMES FROST

Overview of My Research

Dr. J. James Frost received his M.D. and Ph.D. degrees from Washington University; his Ph.D. degree is in nuclear and radiochemistry. He also obtained an M.B.A. degree from John Hopkins University.  Currently, Dr. Frost is President of BioMolecular Imaging and Retired Professor at The Johns Hopkins University School of Medicine, Department of Radiology.

  • Cancer investigator

  • Molecular imaging Specialist

  • Clinical trials reader

  • Clinical radiology and nuclear medicine

  • Consulting for pharma, CROs, diagnostics, and biotech

 
 
Microscope

BIOMOLECULAR IMAGING

Dr. J. James Frost's focus in chemistry was nuclear and radiochemistry, which involved instruction in nuclear structure, quantum mechanics, and higher mathematics. Dr. J. James Frost's areas of focus involve fundamental symmetries and broken symmetries that are the basis of many scientific theories and which pervade the natural world.

"This early exposure and training became reanimated when I conceived and wrote a scientific paper in 2018 on symmetry and symmetry-breaking in cancer " ...a belated demonstration of foundational qualities of chemistry.

Then in Jim founded BioMolecular Imaging Consultants where he provides expert advice on anatomic & molecular imaging from entire organ systems to small molecules, peptides & antibodies for use in early clinical and clinical settings, trial design, data analysis, image reading as well as with all FDA liaisons, CROs and academic imaging sites.

 

CONSULTING PROJECTS

CLINICAL TRIALS

Served as the internal clinical imaging expert for a large public biotech company in a FIH clinical trial for a novel cancer imaging radiolabeled peptide

CORPORATE

Chaired an advisory board meeting for a large US corporation for post approval rollout and a new CNS probe-specific imaging workstation.

IMAGING PARTNERSHIPS

Evaluated U.S. imaging CRO’s for a large international CRO during a multi-month project to select an imaging CRO partner

PUBLIC BIOTECH

Developed an imaging strategy, created imaging protocols, and identified preclinical/clinical imaging sites for an antibody cancer therapeutic program of a public biotech corporation

LARGE PHARMA

Developed and evaluated post approval strategies and phase IV imaging opportunities for a large pharma CNS diagnostic imaging agent

FUNDING

Provided due diligence guidance to a venture capital company in consideration of funding a preclinical CRO start-up. Identified and interfaced with additional VC’s for syndication funding

DRUG CANDIDATES

Advised a large pharma company in the development of an imaging strategy and protocol to examine CNS side effects of a new drug candidate

BUSINESS DEVELOPMENT

Developed a business plan and scientific strategy for a diagnostic cancer imaging start-up company

STRATEGIC PLANNING

Developed an imaging strategy and experimental design for a novel organ imaging need of a small cap pharmaceutical company

 
 
Dr. J. James Frost | Cancer's Computation & Communication
02:51
Dr. J. James Frost

Dr. J. James Frost | Cancer's Computation & Communication

The trade-offs between communication and computation in cancer wasn't something I was thinking about when I wrote Cancer’s Intelligence. I purely considered the computational and decision engine aspects of cancer as an intelligent biologic entity. However, a recent publication entitled Communication consumes 35 times more energy than computation in the human cortex, but both costs are needed to predict synapse number by WB Levy and VG Calvert sharply points out to me that I had omitted an important counterpart of computation: communication. I thought to myself, "Communication or information transfer is essential to transmit the results of an intelligent decision engine of any system to the active components of that system." Since energy is always limited, the optimal balance between computation and communication is a requirement for cancer's efficient survival as a system of genotypically and phenotypically diverse cells, from the primary tumor to the tumor microenvironment to metastases and the metastatic niche. As Levy and Calvert carefully examine the energetic costs for computation and communication in the brain, so must we accomplish the same for cancer, including bits per joule, channel capacity, and maximal entropy constraints on efficiency. In contrast to the human brain, for cancer the goal is to understand computation and communication in order to radically disrupt them and destroy the cancer. Cancer is currently attacked by disrupting communication at the level of cellular receptors and other signaling proteins, but there is no well understood underlying theory to guide treatment from the communication or computation standpoints. In Cancer’s Intelligence I outlined several approaches to the cancer computation problem and in Symmetry and symmetry breaking in cancer: a foundational approach to the cancer problem I outlined some approaches to blocking communication, e.g., attacking cancer network nodes of greatest broken symmetry where network vulnerability is highest. Future cancer investigations will benefit by taking note of the Levy and Calvert work and creating similar theoretical underpinnings for cancer. References: https://www.genengnews.com/news/cancer-cells-seize-signaling-pathway-used-by-neurons-to-metastasize William B Levy https://facultydirectory.virginia.edu/faculty/wbl Victoria G. Calvert https://scholar.google.com/scholar?q=Victoria+G.+Calvert+ Keywords: computation and communication modeling models, physical computing, system functions, scientific study, Trade-offs and Sensor Selection energy For more information on cancer, intelligence, computation, game theory, Boolean network, please view the FULL TEXT HERE CONTACT: E-mail: DRJJAMESFROST@GMAIL.COM Website: www.DrJJamesFrost.com Twitter: www.twitter.com/drjjamesfrost Facebook: www.facebook.com/drjjamesfrost LinkedIn: https://www.linkedin.com/in/drjjamesfrost/ SoundCloud: www.soundcloud.com/drjjamesfrost ORCHID ID: www.orchid.org/0000-0002-5148-6560
Dr  J  James Frost | Cancer's Intelligence Part 3
03:29
Dr. J. James Frost

Dr J James Frost | Cancer's Intelligence Part 3

Dr. J. James Frost Professor emeritus Johns Hopkins University & President of Bio-molecular Imaging, LLC recently published "Cancer's Intelligence" https://www.oldcitypublishing.com/wp-content/uploads/2020/11/IJUCv16n1p41-78Frost.pdf where he talked about how one common manifestation of human computational intelligence is recreational game play, including the most challenging games of chess, go, and poker. A series of recent publications on artificial intelligence for Texas hold’em poker caught Dr. Frost’s eye and led him to contemplate how intelligent a human must be to be an expert poker player and by analogy, how intelligent an oncologist needs to be to beat cancer. If the game against cancer is anything like the poker example, an oncologist would need to possess extremely high intelligence to win in a game with cancer. The question of whether cancer bluffs is one that Dr. Frost examines, looking at dormant periods of cancer growth – when confronted with an onslaught of chemotherapy and radiation – only to restart even faster growth once the oncologist ceases therapy, believing the cancer to be controlled. Read more: https://www.drjjamesfrost.com/cancers-intelligence Is there a parallel to be drawn between bluffing in poker and bluffing in cancer’s game with the oncologist? Video - https://youtu.be/-TY5MRG9fgI Podcast - https://soundcloud.com/drjjamesfrost/dr-j-james-frost-cancers-intelligence-part-3/s-qMkF5SxOVUb Blogpost - https://www.drjjamesfrost.com/cancers-intelligence-part3 Full text - https://www.oldcitypublishing.com/wp-content/uploads/2020/11/IJUCv16n1p41-78Frost.pdf CONTACT: E-mail: DRJJAMESFROST@GMAIL.COM Website: www.DrJJamesFrost.com Twitter: www.twitter.com/drjjamesfrost Facebook: www.facebook.com/drjjamesfrost LinkedIn: https://www.linkedin.com/in/drjjamesfrost/ SoundCloud: www.soundcloud.com/drjjamesfrost ORCHID ID:www.orchid.org/0000-0002-5148-6560

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